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TargetCytochrome P450 17A1
LigandBDBM50296976
Substrate/Competitorn/a
Meas. Tech.ChEMBL_652121
IC50 1040±n/a nM
Citation Owen CPShahid ILee WYAhmed S Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes. Bioorg Med Chem Lett 20:5345-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 17A1
Name:Cytochrome P450 17A1
Synonyms:Cytochrome P450 17,20 lyase | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:Enzyme
Mol. Mass.:57255.68
Organism:Rattus norvegicus (Rat)
Description:P11715
Residue:507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
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  Blast E-value cutoff:
BDBM50296976
n/a
NameBDBM50296976
Synonyms:4-((1H-imidazol-1-yl)methyl)phenyl 4-(trifluoromethyl)benzenesulfonate | CHEMBL560333
TypeSmall organic molecule
Emp. Form.C17H13F3N2O3S
Mol. Mass.382.357
SMILESFC(F)(F)c1ccc(cc1)S(=O)(=O)Oc1ccc(Cn2ccnc2)cc1
Structure
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