Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50325615 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_652285 (CHEMBL1225488) |
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IC50 | 2300±n/a nM |
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Citation | Lucas, MC; Weikert, RJ; Carter, DS; Cai, HY; Greenhouse, R; Iyer, PS; Lin, CJ; Lee, EK; Madera, AM; Moore, A; Ozboya, K; Schoenfeld, RC; Steiner, S; Zhai, Y; Lynch, SM Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain. Bioorg Med Chem Lett20:5559-66 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50325615 |
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n/a |
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Name | BDBM50325615 |
Synonyms: | (7-fluoro-1H-indol-5-yl)(3-propyl pyrrolidin-3-yl)methanone | (7-fluoro-1H-indol-5-yl)(3-propylpyrrolidin-3-yl)methanone | CHEMBL1224402 |
Type | Small organic molecule |
Emp. Form. | C16H19FN2O |
Mol. Mass. | 274.3333 |
SMILES | CCCC1(CCNC1)C(=O)c1cc(F)c2[nH]ccc2c1 |
Structure |
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