Reaction Details |
| Report a problem with these data |
Target | Rho-associated protein kinase 2 |
---|
Ligand | BDBM14027 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_660305 (CHEMBL1249801) |
---|
IC50 | 1900±n/a nM |
---|
Citation | Davies, SP; Reddy, H; Caivano, M; Cohen, P Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J351:95-105 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Rho-associated protein kinase 2 |
---|
Name: | Rho-associated protein kinase 2 |
Synonyms: | ROCK2_RAT | Rho Kinase | Rho-associated protein kinase 2 | Rho-associated protein kinase 2 (ROCK II) | Rho-associated, coiled-coil-containing protein kinase 2 | Rho-associated, coiled-coil-containing protein kinase II | RhoA-binding kinase 2 | Rock2 | p150 ROK-alpha |
Type: | Protein |
Mol. Mass.: | 160370.90 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q62868 |
Residue: | 1388 |
Sequence: | MSRPPPTGKMPGAPEAAAGDGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKSASFFKNDQWN
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRENL
LLSDSPPCRENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLEKT
AKELEEEITFRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLESNNR
DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTGKT
LLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNK
IYESIEEAKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLK
QKDVLNEDVRNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMN
LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQK
KQDLQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDTQEQLSKLKDEEISAAAIKAQF
EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQ
MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPG
DAEPDDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL
DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYICHKG
HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECSRCHIKCHKDHMDKKEEIIAPCKVYYD
ISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR
QLAPNKPS
|
|
|
BDBM14027 |
---|
n/a |
---|
Name | BDBM14027 |
Synonyms: | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4-diazepane-1-sulfonyl)isoquinoline | AT877 | CHEMBL38380 | CHEMBL541388 | Fasudil (HA-1077) | HA-1077 | US9687483, Fasudil | cid_163751 |
Type | Small organic molecule |
Emp. Form. | C14H17N3O2S |
Mol. Mass. | 291.369 |
SMILES | O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 |
Structure |
|