| Reaction Details |
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 | Report a problem with these data |
| Target | Serine palmitoyltransferase 2 |
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| Ligand | BDBM50325998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_660504 (CHEMBL1250175) |
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| IC50 | 10±n/a nM |
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| Citation |  Sakamoto, H; Okamoto, K; Aoki, M; Kato, H; Katsume, A; Ohta, A; Tsukuda, T; Shimma, N; Aoki, Y; Arisawa, M; Kohara, M; Sudoh, M Host sphingolipid biosynthesis as a target for hepatitis C virus therapy. Nat Chem Biol1:333-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine palmitoyltransferase 2 |
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| Name: | Serine palmitoyltransferase 2 |
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| Synonyms: | KIAA0526 | LCB 2 | LCB2 | LCB2a | Long chain base biosynthesis protein 2 | Long chain base biosynthesis protein 2a | SPT 2 | SPTC2_HUMAN | SPTLC2 | Serine-palmitoyl-CoA transferase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62932.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_660504 |
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| Residue: | 562 |
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| Sequence: | MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED
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| BDBM50325998 |
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| n/a |
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| Name | BDBM50325998 |
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| Synonyms: | (S)-2-((S,E)-1-((S)-1-carboxy-2-(4-(3-methylbut-2-enyloxy)phenyl)ethylamino)-1,11-dioxooctadec-3-en-2-yl)-2-hydroxysuccinic acid | CHEMBL1241090 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H53NO10 |
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| Mol. Mass. | 659.8067 |
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| SMILES | [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]\[#6@H](-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8]-[#6]\[#6]=[#6](\[#6])-[#6])cc1)-[#6](-[#8])=O)[C@@]([#8])([#6]-[#6](-[#8])=O)[#6](-[#8])=O |r| |
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| Structure | 
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