| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transcription factor Jun |
|---|
| Ligand | BDBM50326119 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_657293 (CHEMBL1249120) |
|---|
| IC50 | 5700±n/a nM |
|---|
| Citation |  Giri, RS; Thaker, HM; Giordano, T; Chen, B; Nuthalapaty, S; Vasu, KK; Sudarsanam, V Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: inhibitors of multi-pathways involve in cancer. Eur J Med Chem45:3558-63 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transcription factor Jun |
|---|
| Name: | Transcription factor Jun |
|---|
| Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 35683.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05412 |
|---|
| Residue: | 331 |
|---|
| Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
|
|
|
|---|
| BDBM50326119 |
|---|
| n/a |
|---|
| Name | BDBM50326119 |
|---|
| Synonyms: | CHEMBL1242070 | [5-(4-Oxo-3-phenyl-3,4-dihydro-quinazolin-2-yl)-4-phenylthiazol-2-yl]-carbamic acid ethyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H20N4O3S |
|---|
| Mol. Mass. | 468.527 |
|---|
| SMILES | CCOC(=O)Nc1nc(c(s1)-c1nc2ccccc2c(=O)n1-c1ccccc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
