| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor Jun |
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| Ligand | BDBM50326120 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_657293 (CHEMBL1249120) |
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| IC50 | 14000±n/a nM |
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| Citation |  Giri, RS; Thaker, HM; Giordano, T; Chen, B; Nuthalapaty, S; Vasu, KK; Sudarsanam, V Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: inhibitors of multi-pathways involve in cancer. Eur J Med Chem45:3558-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor Jun |
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| Name: | Transcription factor Jun |
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| Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
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| Type: | n/a |
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| Mol. Mass.: | 35683.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05412 |
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| Residue: | 331 |
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| Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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| BDBM50326120 |
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| n/a |
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| Name | BDBM50326120 |
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| Synonyms: | 2-[2-(4-Chloro-phenylamino)-4-phenyl-thiazol-5-yl]-3-(4-methoxy-phenyl)-3H quinazolin-4-one | CHEMBL1242519 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H21ClN4O2S |
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| Mol. Mass. | 537.031 |
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| SMILES | COc1ccc(cc1)-n1c(nc2ccccc2c1=O)-c1sc(Nc2ccc(Cl)cc2)nc1-c1ccccc1 |
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| Structure | 
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