| Reaction Details |
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 | Report a problem with these data |
| Target | Translation factor GUF1, mitochondrial |
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| Ligand | BDBM50326696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_661423 (CHEMBL1252883) |
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| IC50 | 300000±n/a nM |
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| Citation |  Butcher, RA; Bhullar, BS; Perlstein, EO; Marsischky, G; LaBaer, J; Schreiber, SL Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem Biol2:103-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translation factor GUF1, mitochondrial |
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| Name: | Translation factor GUF1, mitochondrial |
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| Synonyms: | EF-4 | Elongation factor 4 homolog | GTPase GUF1 | GUF1 | GUF1_YEAST | Ribosomal back-translocase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73210.19 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_661423 |
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| Residue: | 645 |
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| Sequence: | MLKFRIRPVRHIRCYKRHAYFLRYNHTTTPAQKLQAQIEQIPLENYRNFSIVAHVDHGKS
TLSDRLLEITHVIDPNARNKQVLDKLEVERERGITIKAQTCSMFYKDKRTGKNYLLHLID
TPGHVDFRGEVSRSYASCGGAILLVDASQGIQAQTVANFYLAFSLGLKLIPVINKIDLNF
TDVKQVKDQIVNNFELPEEDIIGVSAKTGLNVEELLLPAIIDRIPPPTGRPDKPFRALLV
DSWYDAYLGAVLLVNIVDGSVRKNDKVICAQTKEKYEVKDIGIMYPDRTSTGTLKTGQVG
YLVLGMKDSKEAKIGDTIMHLSKVNETEVLPGFEEQKPMVFVGAFPADGIEFKAMDDDMS
RLVLNDRSVTLERETSNALGQGWRLGFLGSLHASVFRERLEKEYGSKLIITQPTVPYLVE
FTDGKKKLITNPDEFPDGATKRVNVAAFHEPFIEAVMTLPQEYLGSVIRLCDSNRGEQID
ITYLNTNGQVMLKYYLPLSHLVDDFFGKLKSVSRGFASLDYEDAGYRISDVVKLQLLVNG
NAIDALSRVLHKSEVERVGREWVKKFKEYVKSQLYEVVIQARANNKIIARETIKARRKDV
LQKLHASDVSRRKKLLAKQKEGKKHMKTVGNIQINQEAYQAFLRR
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| BDBM50326696 |
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| n/a |
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| Name | BDBM50326696 |
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| Synonyms: | 6-(phenylamino)quinoline-5,8-dione | 6-Phenylamino-quinoline-5,8-dione | CHEMBL312487 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10N2O2 |
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| Mol. Mass. | 250.2521 |
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| SMILES | O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12 |t:2| |
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| Structure | 
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