Reaction Details |
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Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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Ligand | BDBM50326992 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_663436 (CHEMBL1250984) |
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EC50 | 4500±n/a nM |
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Citation | Melchiorre, M; Del Lungo, M; Guandalini, L; Martini, E; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Sartiani, L; Mugelli, A; Cerbai, E; Romanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
Synonyms: | BCNG-1 | Bcng1 | Brain cyclic nucleotide-gated channel 1 | HAC-2 | HCN1_MOUSE | Hac2 | Hcn1 | Hyperpolarization-activated cation channel 2 |
Type: | PROTEIN |
Mol. Mass.: | 102447.84 |
Organism: | Mus musculus |
Description: | ChEMBL_663436 |
Residue: | 910 |
Sequence: | MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDG
GGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAG
FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLI
MNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTA
RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHW
DGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSD
LWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKI
HDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKL
RFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTA
SVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNT
GVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTAT
SLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQ
QPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPG
SSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPV
AAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPD
AEKPRFASNL
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BDBM50326992 |
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n/a |
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Name | BDBM50326992 |
Synonyms: | CHEMBL471737 | ivabradine |
Type | Small organic molecule |
Emp. Form. | C27H36N2O5 |
Mol. Mass. | 468.5851 |
SMILES | COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC |r| |
Structure |
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