| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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| Ligand | BDBM50326990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_663436 (CHEMBL1250984) |
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| EC50 | 600±n/a nM |
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| Citation |  Melchiorre, M; Del Lungo, M; Guandalini, L; Martini, E; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Sartiani, L; Mugelli, A; Cerbai, E; Romanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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| Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
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| Synonyms: | BCNG-1 | Bcng1 | Brain cyclic nucleotide-gated channel 1 | HAC-2 | HCN1_MOUSE | Hac2 | Hcn1 | Hyperpolarization-activated cation channel 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102447.84 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_663436 |
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| Residue: | 910 |
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| Sequence: | MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDG
GGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAG
FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLI
MNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTA
RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHW
DGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSD
LWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKI
HDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKL
RFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTA
SVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNT
GVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTAT
SLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQ
QPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPG
SSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPV
AAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPD
AEKPRFASNL
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| BDBM50326990 |
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| n/a |
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| Name | BDBM50326990 |
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| Synonyms: | 3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)propylazanediyl)bis(but-2-ene-4,1-diyl))bis(7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one) | CHEMBL1253475 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H51N3O8 |
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| Mol. Mass. | 737.8803 |
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| SMILES | COc1ccc(cc1OC)[C@@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:20,42| |
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| Structure | 
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