| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50327184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664215 (CHEMBL1261656) |
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| Ki | 112±n/a nM |
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| Citation |  Swann, SL; Merta, PJ; Kifle, L; Groebe, D; Sarris, K; Hajduk, PJ; Sun, C Biochemical and biophysical characterization of unique switch pocket inhibitors of p38a. Bioorg Med Chem Lett20:5787-92 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50327184 |
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| n/a |
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| Name | BDBM50327184 |
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| Synonyms: | 5-[3-tert-Butyl-5-(3-naphthalen-1-yl-ureido)-pyrazol-1-yl]-N-((3S,4S)-4-hydroxy-1,1-dioxo-tetrahydro-1lambda6-thiophen-3-yl)-2-methyl-benzamide | CHEMBL1257569 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N5O5S |
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| Mol. Mass. | 575.679 |
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| SMILES | Cc1ccc(cc1C(=O)N[C@@H]1CS(=O)(=O)C[C@H]1O)-n1nc(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C |r| |
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| Structure | 
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