| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50327621 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664675 (CHEMBL1260561) |
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| Ki | 1.08±n/a nM |
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| Citation |  Favor, DA; Powers, JJ; White, AD; Fitzgerald, LW; Groppi, V; Serpa, KA 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics. Bioorg Med Chem Lett20:5666-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50327621 |
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| n/a |
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| Name | BDBM50327621 |
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| Synonyms: | 6-(3-(4-(6-fluoronaphthalen-1-yl)piperazin-1-yl)propoxy)-7-methylisoindolin-1-one | CHEMBL1257736 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28FN3O2 |
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| Mol. Mass. | 433.5178 |
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| SMILES | Cc1c2C(=O)NCc2ccc1OCCCN1CCN(CC1)c1cccc2cc(F)ccc12 |
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| Structure | 
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