| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
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| Ligand | BDBM50327643 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664981 (CHEMBL1259938) |
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| EC50 | >30000±n/a nM |
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| Citation |  Bridges, TM; Kennedy, JP; Hopkins, CR; Conn, PJ; Lindsley, CW Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett20:5617-22 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M5 |
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| Name: | Muscarinic acetylcholine receptor M5 |
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| Synonyms: | ACM5_HUMAN | CHRM5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60102.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517990 |
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| Residue: | 532 |
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| Sequence: | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
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| BDBM50327643 |
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| n/a |
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| Name | BDBM50327643 |
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| Synonyms: | 1-(3,4'-bipyridin-6-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione | CHEMBL1257740 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H12F3N3O3 |
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| Mol. Mass. | 399.3228 |
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| SMILES | FC(F)(F)Oc1ccc2N(Cc3ccc(cn3)-c3ccncc3)C(=O)C(=O)c2c1 |
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| Structure | 
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