| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50328443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_665580 (CHEMBL1261464) |
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| Ki | 19±n/a nM |
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| Citation |  Skultety, M; Hübner, H; Löber, S; Gmeiner, P Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors. J Med Chem53:7219-28 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2 | 5-HT2A | 5HT2A_PIG | HTR2A | Serotonin 2a (5-HT2a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52679.13 |
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| Organism: | PIG |
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| Description: | 5-HT2 0 0::P50129 |
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| Residue: | 470 |
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| Sequence: | MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGAL
LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS
SQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
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| BDBM50328443 |
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| n/a |
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| Name | BDBM50328443 |
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| Synonyms: | 1-(4-Fluorophenyl)-4-[4-([2.2]paracyclophan-4-yl)-4-hydroxypiperidin-1-yl]butan-1-one | CHEMBL1257688 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34FNO2 |
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| Mol. Mass. | 471.6056 |
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| SMILES | OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cc2CCc3ccc(CCc1cc2)cc3 |
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| Structure | 
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