| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1B adrenergic receptor |
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| Ligand | BDBM50328503 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_665657 (CHEMBL1261588) |
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| Ki | 0.9±n/a nM |
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| Citation |  Kristensen, JL; Püschl, A; Jensen, M; Risgaard, R; Christoffersen, CT; Bang-Andersen, B; Balle, T Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity fora(1)-adrenoceptors. J Med Chem53:7021-34 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1B adrenergic receptor |
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| Name: | Alpha-1B adrenergic receptor |
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| Synonyms: | ADA1B_MESAU | ADRA1B | Adrenergic receptor alpha | Alpha-1b adrenergic receptor | adrenergic Alpha1B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56514.13 |
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| Organism: | C.H.O. |
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| Description: | adrenergic Alpha1B ADRA1B C.H.O.::P18841 |
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| Residue: | 515 |
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| Sequence: | MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLP
SASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESP
GTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
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| BDBM50328503 |
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| n/a |
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| Name | BDBM50328503 |
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| Synonyms: | (R)-N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrodibenzo[b,f]thiepin-2-yl)methyl)acetamide | CHEMBL1259173 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N3OS |
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| Mol. Mass. | 381.534 |
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| SMILES | CN1CCN(CC1)[C@@H]1Cc2ccccc2Sc2ccc(CNC(C)=O)cc12 |r| |
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| Structure | 
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