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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 8 | ||
| Ligand | BDBM50323168 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_673774 (CHEMBL1274951) | ||
| Ki | 7830±n/a nM | ||
| Citation |  O'Connor, SP; Wang, Y; Simpkins, LM; Brigance, RP; Meng, W; Wang, A; Kirby, MS; Weigelt, CA; Hamann, LG Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors. Bioorg Med Chem Lett20:6273-6 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 8 | |||
| Name: | Dipeptidyl peptidase 8 | ||
| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 103342.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q6V1X1 | ||
| Residue: | 898 | ||
| Sequence: |
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| BDBM50323168 | |||
| n/a | |||
| Name | BDBM50323168 | ||
| Synonyms: | (5-(2,4-dichlorophenyl)-2-(2-methoxyphenyl)-7-methylimidazo[1,2-a]pyrimidin-6-yl)methanamine | CHEMBL1208901 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H18Cl2N4O | ||
| Mol. Mass. | 413.3 | ||
| SMILES | COc1ccccc1-c1cn2c(c(CN)c(C)nc2n1)-c1ccc(Cl)cc1Cl |(31.42,-35.45,;32.17,-34.11,;31.39,-32.79,;29.85,-32.8,;29.07,-31.47,;29.83,-30.13,;31.37,-30.12,;32.15,-31.45,;33.68,-31.44,;34.6,-32.69,;36.07,-32.2,;37.4,-32.96,;38.73,-32.19,;40.07,-32.95,;41.4,-32.18,;38.73,-30.65,;40.06,-29.87,;37.39,-29.88,;36.06,-30.65,;34.58,-30.19,;37.41,-34.49,;36.08,-35.26,;36.08,-36.81,;37.41,-37.58,;37.41,-39.12,;38.75,-36.81,;38.74,-35.26,;40.07,-34.48,)| | ||
| Structure | 
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