| Reaction Details |
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 | Report a problem with these data |
| Target | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
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| Ligand | BDBM50329092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674193 (CHEMBL1274290) |
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| IC50 | >122000±n/a nM |
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| Citation |  Li, X; Liu, N; Zhang, H; Knudson, SE; Slayden, RA; Tonge, PJ Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett20:6306-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,4-dihydroxy-2-naphthoyl-CoA synthase |
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| Name: | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
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| Synonyms: | DHNA-CoA synthase | MENB_MYCTU | menB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34688.06 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_817596 |
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| Residue: | 314 |
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| Sequence: | MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNA
FRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASG
DTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYAR
FKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELE
TVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFL
QKRPPDWSPFPRYF
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| BDBM50329092 |
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| n/a |
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| Name | BDBM50329092 |
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| Synonyms: | (Z)-methyl 2-(3-oxo-3,4-dihydroquinoxalin-2(1H)-ylidene)acetate | CHEMBL1269433 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10N2O3 |
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| Mol. Mass. | 218.2087 |
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| SMILES | COC(=O)Cc1nc2ccccc2[nH]c1=O |
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| Structure | 
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