| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM50329587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674957 (CHEMBL1272634) |
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| Ki | 7085±n/a nM |
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| Citation |  Gluszok, S; Frédérick, R; Foulon, C; Klupsch, F; Supuran, CT; Vullo, D; Scozzafava, A; Goossens, JF; Masereel, B; Depreux, P; Goossens, L Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors. Bioorg Med Chem18:7392-401 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase 1 |
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| Synonyms: | CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM50329587 |
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| n/a |
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| Name | BDBM50329587 |
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| Synonyms: | 4-[2-Methyl-3-[(4-methylpiperazino)carbonyl]-5-(4-biphenylyl)-1H-1-pyrrolyl]-1-benzenesulfonamide | CHEMBL1271041 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N4O3S |
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| Mol. Mass. | 514.639 |
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| SMILES | CN1CCN(CC1)C(=O)c1cc(-c2ccc(cc2)-c2ccccc2)n(c1C)-c1ccc(cc1)S(N)(=O)=O |
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| Structure | 
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