Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 9 |
---|
Ligand | BDBM50329604 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_674959 (CHEMBL1272636) |
---|
Ki | 126±n/a nM |
---|
Citation | Gluszok, S; Frédérick, R; Foulon, C; Klupsch, F; Supuran, CT; Vullo, D; Scozzafava, A; Goossens, JF; Masereel, B; Depreux, P; Goossens, L Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors. Bioorg Med Chem18:7392-401 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 9 |
---|
Name: | Carbonic anhydrase 9 |
Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
Type: | Enzyme |
Mol. Mass.: | 49669.03 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 459 |
Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
BDBM50329604 |
---|
n/a |
---|
Name | BDBM50329604 |
Synonyms: | CHEMBL1270632 | N-[2-(4-Methylpiperazino)ethyl]-1-[4-(aminosulfonyl)-phenyl]-2-methyl-5-(2-naphthyl)-1H-pyrrole-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C29H33N5O3S |
Mol. Mass. | 531.669 |
SMILES | CN1CCN(CCNC(=O)c2cc(-c3ccc4ccccc4c3)n(c2C)-c2ccc(cc2)S(N)(=O)=O)CC1 |
Structure |
|