| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50330180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_676201 (CHEMBL1273321) |
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| IC50 | >100000±n/a nM |
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| Citation |  Jiaranaikulwanitch, J; Boonyarat, C; Fokin, VV; Vajragupta, O Triazolyl tryptoline derivatives asß-secretase inhibitors. Bioorg Med Chem Lett20:6572-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50330180 |
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| n/a |
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| Name | BDBM50330180 |
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| Synonyms: | (S)-3-((4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | CHEMBL1272322 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N5O |
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| Mol. Mass. | 409.483 |
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| SMILES | COc1ccc2cc(ccc2c1)-c1cn(C[C@@H]2Cc3c(CN2)[nH]c2ccccc32)nn1 |r| |
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| Structure | 
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