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TargetPurine Nucleoside Phosphorylase (PNP)
LigandBDBM50330389
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684503
IC50 366000±n/a nM
Citation Cui HRuda GFCarrero-Lérida JRuiz-Pérez LMGilbert IHGonzález-Pacanowska D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article
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Purine Nucleoside Phosphorylase (PNP)
Name:Purine Nucleoside Phosphorylase (PNP)
Synonyms:pfPNP
Type:Enzyme
Mol. Mass.:26857.85
Organism:Plasmodium falciparum
Description:n/a
Residue:245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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BDBM50330389
n/a
NameBDBM50330389
Synonyms:3-((2-(l-Prolinol)-1-yl)-ethyl)uracil | CHEMBL1275721
TypeSmall organic molecule
Emp. Form.C11H17N3O3
Mol. Mass.239.271
SMILESOC[C@@H]1CCCN1CCn1c(=O)cc[nH]c1=O |r|
Structure
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