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TargetPurine Nucleoside Phosphorylase (PNP)
LigandBDBM50330397
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684503
IC50 524000±n/a nM
Citation Cui HRuda GFCarrero-Lérida JRuiz-Pérez LMGilbert IHGonzález-Pacanowska D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article
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Purine Nucleoside Phosphorylase (PNP)
Name:Purine Nucleoside Phosphorylase (PNP)
Synonyms:pfPNP
Type:Enzyme
Mol. Mass.:26857.85
Organism:Plasmodium falciparum
Description:n/a
Residue:245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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BDBM50330397
n/a
NameBDBM50330397
Synonyms:1-((4-Pyrrolidine-1-yl)-butyl)uracil | CHEMBL1275702
TypeSmall organic molecule
Emp. Form.C12H19N3O2
Mol. Mass.237.2982
SMILESO=c1ccn(CCCCN2CCCC2)c(=O)[nH]1
Structure
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