| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 |
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| Ligand | BDBM50330577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_685030 (CHEMBL1286646) |
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| IC50 | 2300±n/a nM |
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| Citation |  Whelligan, DK; Solanki, S; Taylor, D; Thomson, DW; Cheung, KM; Boxall, K; Mas-Droux, C; Barillari, C; Burns, S; Grummitt, CG; Collins, I; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem53:7682-98 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek2 |
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| Name: | Serine/threonine-protein kinase Nek2 |
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| Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51776.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51955 |
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| Residue: | 445 |
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| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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| BDBM50330577 |
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| n/a |
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| Name | BDBM50330577 |
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| Synonyms: | 4-(3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)-2-methylbenzoic acid | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid | CHEMBL1230337 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N3O5 |
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| Mol. Mass. | 395.4085 |
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| SMILES | COc1cc(cc(OC)c1OC)-c1cnc(N)c(n1)-c1ccc(C(O)=O)c(C)c1 |
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| Structure | 
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