| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 1 |
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| Ligand | BDBM50330722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_685172 (CHEMBL1286988) |
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| Ki | 165±n/a nM |
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| Citation |  Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 1 |
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| Name: | NADPH oxidase 1 |
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| Synonyms: | MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64890.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792877 |
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| Residue: | 564 |
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| Sequence: | MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
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| BDBM50330722 |
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| n/a |
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| Name | BDBM50330722 |
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| Synonyms: | 2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1276946 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15ClN4O2 |
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| Mol. Mass. | 366.801 |
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| SMILES | Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12 |
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| Structure | 
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