| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cruzipain |
|---|
| Ligand | BDBM50114653 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_683902 (CHEMBL1285900) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Hernandes, MZ; Rabello, MM; Leite, AC; Cardoso, MV; Moreira, DR; Brondani, DJ; Simone, CA; Reis, LC; Souza, MA; Pereira, VR; Ferreira, RS; McKerrow, JH Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorg Med Chem18:7826-35 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cruzipain |
|---|
| Name: | Cruzipain |
|---|
| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 49831.41 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | P25779 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
|
|
|
|---|
| BDBM50114653 |
|---|
| n/a |
|---|
| Name | BDBM50114653 |
|---|
| Synonyms: | (1E)-1-(3,4-dichlorophenyl)ethan-1-one thiosemicarbazone | CHEMBL90512 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H9Cl2N3S |
|---|
| Mol. Mass. | 262.159 |
|---|
| SMILES | CC(=NNC(N)=S)c1ccc(Cl)c(Cl)c1 |w:2.2| |
|---|
| Structure | 
|
|---|
Search and Browse
