| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase |
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| Ligand | BDBM50331183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_686384 (CHEMBL1293140) |
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| IC50 | 87±n/a nM |
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| Citation |  Wheatley, NC; Andrews, KT; Tran, TL; Lucke, AJ; Reid, RC; Fairlie, DP Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. Bioorg Med Chem Lett20:7080-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase |
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| Name: | Histone deacetylase |
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| Synonyms: | Histone Deacetylase (pfHDAC-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51371.91 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | Assays were performed using recombinant pfHDAC-1 expressed and purified from S2 insect cells. |
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| Residue: | 449 |
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| Sequence: | MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNEL
TLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGAS
KLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDG
VEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFK
VVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGG
YTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLS
RIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKE
HSTTHHLRRKNYDDDFFDLSDRDQSIVPY
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| BDBM50331183 |
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| n/a |
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| Name | BDBM50331183 |
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| Synonyms: | (S)-2-cinnamamido-N8-hydroxy-N1-(quinolin-8-yl)octanediamide | CHEMBL220692 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N4O4 |
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| Mol. Mass. | 460.5249 |
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| SMILES | ONC(=O)CCCCC[C@H](NC(=O)\C=C\c1ccccc1)C(=O)Nc1cccc2cccnc12 |r| |
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| Structure | 
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