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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50331306 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_686645 (CHEMBL1292498) | ||
| Ki | 10±n/a nM | ||
| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein | ||
| Type: | Protein | ||
| Mol. Mass.: | 25307.17 | ||
| Organism: | Cavia porcellus (Guinea pig) | ||
| Description: | Q60492 | ||
| Residue: | 223 | ||
| Sequence: |
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| BDBM50331306 | |||
| n/a | |||
| Name | BDBM50331306 | ||
| Synonyms: | CHEMBL1289057 | cis-7-(Benzyloxy)-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33NO2 | ||
| Mol. Mass. | 427.5778 | ||
| SMILES | OC1CN(CCc2cc(OCc3ccccc3)ccc12)[C@H]1CC[C@H](CC1)c1ccccc1 |r,wD:20.22,23.29,(-.38,6.74,;-0,5.31,;1.51,5.06,;2.27,3.64,;1.62,2.21,;.11,1.85,;-1.16,2.84,;-2.46,2.1,;-3.74,2.84,;-5.03,2.1,;-6.31,2.84,;-7.59,2.09,;-8.88,2.83,;-10.16,2.08,;-10.16,.6,;-8.88,-.15,;-7.59,.6,;-3.75,4.32,;-2.48,5.07,;-1.18,4.34,;3.86,3.63,;4.66,2.24,;6.26,2.23,;7.08,3.61,;6.29,5.01,;4.67,5.02,;8.68,3.59,;9.46,2.19,;11.06,2.17,;11.88,3.56,;11.08,4.96,;9.48,4.96,)| | ||
| Structure | 
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