Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50331307 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_686645 (CHEMBL1292498) | ||
| Ki | 386±n/a nM | ||
| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein | ||
| Type: | Protein | ||
| Mol. Mass.: | 25307.17 | ||
| Organism: | Cavia porcellus (Guinea pig) | ||
| Description: | Q60492 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50331307 | |||
| n/a | |||
| Name | BDBM50331307 | ||
| Synonyms: | CHEMBL1289058 | trans-7-(Benzyloxy)-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33NO2 | ||
| Mol. Mass. | 427.5778 | ||
| SMILES | OC1CN(CCc2cc(OCc3ccccc3)ccc12)[C@H]1CC[C@@H](CC1)c1ccccc1 |r,wU:23.29,wD:20.22,(25.44,6.92,;25.82,5.49,;27.33,5.24,;28.09,3.82,;27.44,2.39,;25.93,2.03,;24.66,3.02,;23.36,2.28,;22.08,3.02,;20.8,2.28,;19.51,3.02,;18.23,2.27,;16.94,3.01,;15.66,2.26,;15.66,.78,;16.94,.03,;18.24,.78,;22.07,4.5,;23.34,5.25,;24.65,4.52,;29.69,3.83,;30.49,2.44,;32.1,2.44,;32.9,3.82,;32.1,5.22,;30.48,5.22,;34.5,3.82,;35.29,2.43,;36.9,2.43,;37.7,3.81,;36.89,5.21,;35.29,5.2,)| | ||
| Structure | 
| ||