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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50331318 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_686645 (CHEMBL1292498) | ||
| Ki | 200±n/a nM | ||
| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein | ||
| Type: | Protein | ||
| Mol. Mass.: | 25307.17 | ||
| Organism: | Cavia porcellus (Guinea pig) | ||
| Description: | Q60492 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50331318 | |||
| n/a | |||
| Name | BDBM50331318 | ||
| Synonyms: | (+/-)-trans-3-(4-Phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol | CHEMBL1289954 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27NO2 | ||
| Mol. Mass. | 337.4553 | ||
| SMILES | OC1CN(CCc2cc(O)ccc12)[C@H]1CC[C@@H](CC1)c1ccccc1 |r,wU:16.21,wD:13.14,(16.06,-12.53,;16.44,-13.97,;17.95,-14.23,;18.71,-15.64,;18.07,-17.08,;16.55,-17.44,;15.27,-16.44,;13.98,-17.18,;12.68,-16.43,;11.4,-17.19,;12.68,-14.96,;13.96,-14.21,;15.26,-14.94,;20.32,-15.64,;21.12,-17.03,;22.72,-17.03,;23.53,-15.65,;22.72,-14.25,;21.11,-14.25,;25.06,-15.65,;25.83,-16.99,;27.37,-17,;28.14,-15.66,;27.37,-14.32,;25.83,-14.32,)| | ||
| Structure | 
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