| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin K-dependent protein C |
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| Ligand | BDBM50331664 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_687653 (CHEMBL1290977) |
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| IC50 | 395300±n/a nM |
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| Citation |  Hanessian, S; Larsson, A; Fex, T; Knecht, W; Blomberg, N Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. Bioorg Med Chem Lett20:6925-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin K-dependent protein C |
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| Name: | Vitamin K-dependent protein C |
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| Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 52067.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 461 |
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| Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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| BDBM50331664 |
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| n/a |
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| Name | BDBM50331664 |
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| Synonyms: | (4S,7R)-18-chloro-7-cyclohexyl-4-isobutyl-4,5,7,8,11,12,13,14-octahydro-1H-[1,4,7]triazacyclohexadeca[10,9-b]indole-3,6,9(2H,10H,15H)-trione | CHEMBL1290179 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41ClN4O3 |
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| Mol. Mass. | 529.114 |
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| SMILES | CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)CCCCCc2[nH]c3ccc(Cl)cc3c2CNC1=O)C1CCCCC1 |r| |
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| Structure | 
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