| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Triosephosphate isomerase, glycosomal |
|---|
| Ligand | BDBM50332792 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_696637 (CHEMBL1641188) |
|---|
| IC50 | 20000±n/a nM |
|---|
| Citation |  Alvarez, G; Aguirre-López, B; Varela, J; Cabrera, M; Merlino, A; López, GV; Lavaggi, ML; Porcal, W; Di Maio, R; González, M; Cerecetto, H; Cabrera, N; Pérez-Montfort, R; de Gómez-Puyou, MT; Gómez-Puyou, A Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. Eur J Med Chem45:5767-72 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Triosephosphate isomerase, glycosomal |
|---|
| Name: | Triosephosphate isomerase, glycosomal |
|---|
| Synonyms: | TIM | TPIS_TRYCR | Triose-phosphate isomerase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27334.70 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | ChEMBL_596695 |
|---|
| Residue: | 251 |
|---|
| Sequence: | MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPK
FQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAA
GFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVAT
PQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLK
PEFVEIIEATK
|
|
|
|---|
| BDBM50332792 |
|---|
| n/a |
|---|
| Name | BDBM50332792 |
|---|
| Synonyms: | 4-(5-Nitro-furan-2-ylmethylene)-1,1-dioxo-1,4-dihydro-1lambda*6*-[1,2, 6]thiadiazine-3,5-diamine | CHEMBL1630893 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H7N5O5S |
|---|
| Mol. Mass. | 285.237 |
|---|
| SMILES | NC1=NS(=O)(=O)NC(=N)C1=Cc1ccc(o1)[N+]([O-])=O |w:10.11,t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
