| Reaction Details |
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 | Report a problem with these data |
| Target | Triosephosphate isomerase, glycosomal |
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| Ligand | BDBM50332793 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_696637 (CHEMBL1641188) |
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| IC50 | 13000±n/a nM |
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| Citation |  Alvarez, G; Aguirre-López, B; Varela, J; Cabrera, M; Merlino, A; López, GV; Lavaggi, ML; Porcal, W; Di Maio, R; González, M; Cerecetto, H; Cabrera, N; Pérez-Montfort, R; de Gómez-Puyou, MT; Gómez-Puyou, A Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. Eur J Med Chem45:5767-72 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Triosephosphate isomerase, glycosomal |
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| Name: | Triosephosphate isomerase, glycosomal |
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| Synonyms: | TIM | TPIS_TRYCR | Triose-phosphate isomerase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27334.70 |
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| Organism: | Trypanosoma cruzi |
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| Description: | ChEMBL_596695 |
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| Residue: | 251 |
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| Sequence: | MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPK
FQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAA
GFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVAT
PQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLK
PEFVEIIEATK
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| BDBM50332793 |
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| n/a |
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| Name | BDBM50332793 |
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| Synonyms: | 2,6-Dibenzyl-4-(5-nitro-furan-2-ylm ethylene)-1,1-dioxo-1lambda*6*-[1,2 ,6]thiadiazinane-3,5-dione | CHEMBL1630897 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17N3O7S |
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| Mol. Mass. | 467.451 |
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| SMILES | [#8-]-[#7+](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7](-[#6]-c3ccccc3)S(=O)(=O)[#7](-[#6]-c3ccccc3)-[#6]-2=O)o1 |
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| Structure | 
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