| Reaction Details |
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 | Report a problem with these data |
| Target | Triosephosphate isomerase, glycosomal |
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| Ligand | BDBM50332795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_696637 (CHEMBL1641188) |
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| IC50 | 3500±n/a nM |
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| Citation |  Alvarez, G; Aguirre-López, B; Varela, J; Cabrera, M; Merlino, A; López, GV; Lavaggi, ML; Porcal, W; Di Maio, R; González, M; Cerecetto, H; Cabrera, N; Pérez-Montfort, R; de Gómez-Puyou, MT; Gómez-Puyou, A Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. Eur J Med Chem45:5767-72 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Triosephosphate isomerase, glycosomal |
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| Name: | Triosephosphate isomerase, glycosomal |
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| Synonyms: | TIM | TPIS_TRYCR | Triose-phosphate isomerase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27334.70 |
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| Organism: | Trypanosoma cruzi |
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| Description: | ChEMBL_596695 |
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| Residue: | 251 |
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| Sequence: | MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPK
FQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAA
GFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVAT
PQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLK
PEFVEIIEATK
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| BDBM50332795 |
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| n/a |
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| Name | BDBM50332795 |
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| Synonyms: | 3-(4-methylphenyl)-5-oxo-4,5-dihydro-1,2,4-thiadiazole | 3-p-tolyl-1,2,4-thiadiazol-5(4H)-one | CHEMBL258634 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H8N2OS |
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| Mol. Mass. | 192.238 |
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| SMILES | Cc1ccc(cc1)-c1nc(=O)s[nH]1 |
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| Structure | 
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