Ki Summary

Reaction Details

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Target

Galactofuranosyltransferase GlfT2

Ligand

BDBM50333187

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_698125 (CHEMBL1646238)

IC50

332000±n/a nM

Citation

Vembaiyan, K; Pearcey, JA; Bhasin, M; Lowary, TL; Zou, W Synthesis of sugar-amino acid-nucleosides as potential glycosyltransferase inhibitors. Bioorg Med Chem19:58-66 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Galactofuranosyltransferase GlfT2

Name:

Galactofuranosyltransferase GlfT2

Synonyms:

GLFT2_MYCTU | UDP-galactofuranosyl transferase GlfT2 | glfT | glfT2

Type:

PROTEIN

Mol. Mass.:

71513.75

Organism:

Mycobacterium tuberculosis

Description:

ChEMBL_698125

Residue:

637

Sequence:

MSELAASLLSRVILPRPGEPLDVRKLYLEESTTNARRAHAPTRTSLQIGAESEVSFATYF
NAFPASYWRRWTTCKSVVLRVQVTGAGRVDVYRTKATGARIFVEGHDFTGTEDQPAAVET
EVVLQPFEDGGWVWFDITTDTAVTLHSGGWYATSPAPGTANIAVGIPTFNRPADCVNALR
ELTADPLVDQVIGAVIVPDQGERKVRDHPDFPAAAARLGSRLSIHDQPNLGGSGGYSRVM
YEALKNTDCQQILFMDDDIRLEPDSILRVLAMHRFAKAPMLVGGQMLNLQEPSHLHIMGE
VVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSKLLHRRIDVDYNGWWTCMIPRQVAEEL
GQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKDDAIDWQAYFHLRNRLVV
AAMHWDGPKAQVIGLVRSHLKATLKHLACLEYSTVAIQNKAIDDFLAGPEHIFSILESAL
PQVHRIRKSYPDAVVLPAASELPPPLHKNKAMKPPVNPLVIGYRLARGIMHNLTAANPQH
HRRPEFNVPTQDARWFLLCTVDGATVTTADGCGVVYRQRDRAKMFALLWQSLRRQRQLLK
RFEEMRRIYRDALPTLSSKQKWETALLPAANQEPEHG

BDBM50333187

n/a

Name

BDBM50333187

Synonyms:

5'-N-[N-alpha-(2,6-Anhydro-D-glycero-L-gluco-heptit-1-yl-acetamido)-histidinamido]-5'-deoxy-uridine | CHEMBL1644891

Type

Small organic molecule

Emp. Form.

C23H32N6O12

Mol. Mass.

584.5332

SMILES

OC[C@H]1O[C@H](CC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)NC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O |r|

Structure