Reaction Details |
| Report a problem with these data |
Target | Macrophage metalloelastase |
---|
Ligand | BDBM50333938 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_700258 (CHEMBL1647476) |
---|
IC50 | 200±n/a nM |
---|
Citation | Badland, M; Compère, D; Courté, K; Dublanchet, AC; Blais, S; Manage, A; Peron, G; Wrigglesworth, R Thiophene and bioisostere derivatives as new MMP12 inhibitors. Bioorg Med Chem Lett21:528-30 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Macrophage metalloelastase |
---|
Name: | Macrophage metalloelastase |
Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
Type: | Enzyme |
Mol. Mass.: | 54012.99 |
Organism: | Homo sapiens (Human) |
Description: | P39900 |
Residue: | 470 |
Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
BDBM50333938 |
---|
n/a |
---|
Name | BDBM50333938 |
Synonyms: | (R)-3-(5-fluoro-4-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamido)-3-phenylpropanoic acid | CHEMBL1644427 |
Type | Small organic molecule |
Emp. Form. | C21H15F4NO4S |
Mol. Mass. | 453.407 |
SMILES | OC(=O)C[C@@H](NC(=O)c1cc(c(F)s1)-c1ccc(OC(F)(F)F)cc1)c1ccccc1 |r| |
Structure |
|