Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent noradrenaline transporter |
---|
Ligand | BDBM50333971 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_700294 (CHEMBL1647512) |
---|
IC50 | 148±n/a nM |
---|
Citation | Angus, D; Bingham, M; Buchanan, D; Dunbar, N; Gibson, L; Goodwin, R; Haunsø, A; Houghton, A; Huggett, M; Morphy, R; Napier, S; Nimz, O; Passmore, J; Walker, G The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain. Bioorg Med Chem Lett21:271-5 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent noradrenaline transporter |
---|
Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
|
|
|
BDBM50333971 |
---|
n/a |
---|
Name | BDBM50333971 |
Synonyms: | CHEMBL1644604 | exo-5-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)biphenyl-3-carbonitrile |
Type | Small organic molecule |
Emp. Form. | C20H20N2O |
Mol. Mass. | 304.3856 |
SMILES | N#Cc1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3)cc(c1)-c1ccccc1 |r| |
Structure |
|