| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50334161 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_698206 (CHEMBL1646511) |
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| Ki | 0.57±n/a nM |
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| Citation |  Maestrup, EG; Wiese, C; Schepmann, D; Brust, P; Wünsch, B Synthesis, pharmacological activity and structure affinity relationships of spirocyclics(1) receptor ligands with a (2-fluoroethyl) residue in 3-position. Bioorg Med Chem19:393-405 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50334161 |
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| n/a |
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| Name | BDBM50334161 |
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| Synonyms: | 1'-(4-fluorobenzyl)-3-(2-fluoroethyl)-3H-spiro[isobenzofuran-1,4'-piperidine] | CHEMBL1645205 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F2NO |
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| Mol. Mass. | 343.4102 |
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| SMILES | FCCC1OC2(CCN(Cc3ccc(F)cc3)CC2)c2ccccc12 |
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| Structure | 
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