| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 [K65Q] |
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| Ligand | BDBM50334181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_698222 (CHEMBL1646527) |
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| IC50 | 110±n/a nM |
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| Citation |  Maccari, R; Del Corso, A; Giglio, M; Moschini, R; Mura, U; Ottanà, R In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors. Bioorg Med Chem Lett21:200-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 [K65Q] |
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| Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
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| Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
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| Type: | Protein |
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| Mol. Mass.: | 35916.27 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P16116[K65Q] |
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| Residue: | 315 |
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| Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
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| BDBM50334181 |
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| n/a |
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| Name | BDBM50334181 |
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| Synonyms: | 2-(4-oxo-5-(4-phenoxybenzylidene)-2-thioxothiazolidin-3-yl)acetic acid | CHEMBL1645387 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13NO4S2 |
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| Mol. Mass. | 371.43 |
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| SMILES | OC(=O)CN1C(=S)S\C(=C/c2ccc(Oc3ccccc3)cc2)C1=O |
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| Structure | 
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