| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Ligand | BDBM50274894 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_698222 (CHEMBL1646527) |
|---|
| IC50 | 2270±n/a nM |
|---|
| Citation |  Maccari, R; Del Corso, A; Giglio, M; Moschini, R; Mura, U; Ottanà, R In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors. Bioorg Med Chem Lett21:200-3 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35916.27 |
|---|
| Organism: | Bos taurus (Cattle) |
|---|
| Description: | P16116[K65Q] |
|---|
| Residue: | 315 |
|---|
| Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
|
|
|
|---|
| BDBM50274894 |
|---|
| n/a |
|---|
| Name | BDBM50274894 |
|---|
| Synonyms: | (Z)-5-(Naphthalen-1'-ylmethylene)-2-thioxothiazolidin-4-one | (Z)-5-(Naphthalen-1-ylmethylene)-2-thioxothiazolidin-4-one | CHEMBL457747 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H9NOS2 |
|---|
| Mol. Mass. | 271.357 |
|---|
| SMILES | SC1=NC(=O)C(S1)=Cc1cccc2ccccc12 |w:7.8,t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
