| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Ligand | BDBM50417647 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_699418 (CHEMBL1647445) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Pizzi, DA; Leslie, CP; Di Fabio, R; Seri, C; Bernasconi, G; Squaglia, M; Carnevale, G; Falchi, A; Greco, E; Mangiarini, L; Negri, M Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorg Med Chem Lett21:602-5 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Synonyms: | GABA transporter 1 | GABATR | GABT1 | GAT-1 | GAT1 | SC6A1_HUMAN | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67079.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1454196 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
|
|
|
|---|
| BDBM50417647 |
|---|
| n/a |
|---|
| Name | BDBM50417647 |
|---|
| Synonyms: | CHEMBL1642409 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23NO2S2 |
|---|
| Mol. Mass. | 373.532 |
|---|
| SMILES | [#6]-c1ccc(s1)-[#6](=[#6]/[#6]-[#6]-[#7]-1-[#6]-[#6@H]-2-[#6@@H](-[#6]-1)-[#6@@H]-2-[#6](-[#8])=O)\c1ccc(-[#6])s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
