| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
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| Ligand | BDBM50417658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_699418 (CHEMBL1647445) |
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| Ki | 691.83±n/a nM |
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| Citation |  Pizzi, DA; Leslie, CP; Di Fabio, R; Seri, C; Bernasconi, G; Squaglia, M; Carnevale, G; Falchi, A; Greco, E; Mangiarini, L; Negri, M Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorg Med Chem Lett21:602-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 1 |
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| Name: | Sodium- and chloride-dependent GABA transporter 1 |
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| Synonyms: | GABA transporter 1 | GABATR | GABT1 | GAT-1 | GAT1 | SC6A1_HUMAN | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67079.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454196 |
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| Residue: | 599 |
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| Sequence: | MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
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| BDBM50417658 |
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| n/a |
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| Name | BDBM50417658 |
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| Synonyms: | CHEMBL1642372 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F2NO2 |
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| Mol. Mass. | 371.4203 |
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| SMILES | OC(=O)[C@@H]1CCCN(CC\C=C(/c2ccccc2)c2c(F)cccc2F)C1 |r| |
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| Structure | 
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