| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-6 |
|---|
| Ligand | BDBM50334474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_701134 (CHEMBL1648232) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Zhang, Z; Zheng, G; Pivavarchyk, M; Deaciuc, AG; Dwoskin, LP; Crooks, PA Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett21:88-91 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-6 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-6 |
|---|
| Synonyms: | ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56943.53 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1454451 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVT
VHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDI
VLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
YDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVI
PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLD
KTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTE
NSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVG
LFLQPLLGNTGAS
|
|
|
|---|
| BDBM50334474 |
|---|
| n/a |
|---|
| Name | BDBM50334474 |
|---|
| Synonyms: | 1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetrayl)tetrakis(pentane-5,1-diyl))tetrakis(3-(3-hydroxypropyl)pyridinium) bromide | 1,2,4,5-tetrakis-{5-[(3-(3-hydroxypropyl)-pyridinium)]-pentanyl}-benzene tetrabromide | CHEMBL451671 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C58H86N4O4 |
|---|
| Mol. Mass. | 903.3256 |
|---|
| SMILES | OCCCc1ccc[n+](CCCCCc2cc(CCCCC[n+]3cccc(CCCO)c3)c(CCCCC[n+]3cccc(CCCO)c3)cc2CCCCC[n+]2cccc(CCCO)c2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
