| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM50334843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_699547 (CHEMBL1647802) |
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| EC50 | 0.5±n/a nM |
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| Citation |  Luckhurst, CA; Stein, LA; Furber, M; Webb, N; Ratcliffe, MJ; Allenby, G; Botterell, S; Tomlinson, W; Martin, B; Walding, A Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists. Bioorg Med Chem Lett21:492-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 49910.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q03181 |
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| Residue: | 441 |
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| Sequence: | MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
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| BDBM50334843 |
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| n/a |
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| Name | BDBM50334843 |
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| Synonyms: | (R)-2-(4-((3-(2,4-dichlorophenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-2-methylphenoxy)acetic acid | CHEMBL1643201 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24Cl2N2O4 |
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| Mol. Mass. | 499.386 |
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| SMILES | Cc1cc(CN2Cc3ccccc3C[C@@H]2C(=O)Nc2ccc(Cl)cc2Cl)ccc1OCC(O)=O |r| |
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| Structure | 
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