| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal alpha-glucosidase |
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| Ligand | BDBM50312527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701785 (CHEMBL1656922) |
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| IC50 | 1000000±n/a nM |
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| Citation |  Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars ACS Med Chem Lett2:119-123 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal alpha-glucosidase |
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| Name: | Lysosomal alpha-glucosidase |
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| Synonyms: | α-Glucosidase | Acid maltase | Gaa | LYAG_MOUSE | Lysosomal alpha-glucosidase | alpha-glucosidase (Gaa) |
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| Type: | Enzyme |
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| Mol. Mass.: | 106235.32 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P70699 |
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| Residue: | 953 |
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| Sequence: | MNIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEG
YKPGPLHIQEQTEQPKEAPTQCDVPPSSRFDCAPDKGISQEQCEARGCCYVPAGQVLKEP
QIGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLH
FKIKDPASKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLF
FADQFLQLSTSLPSQHITGLGEHLSPLMLSTDWARITLWNRDTPPSQGTNLYGSHPFYLA
LEDGGLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDS
FADFPDMVRELHQDGRRYMMIVDPAISSAGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGTTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWLDMNEPSNFVRGSQQGCPNNELEN
PPYVPGVVGGILQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISR
STFSGHGRYAGHWTGDVRSSWEHLAYSVPDILQFNLLGVPLVGADICGFIGDTSEELCVR
WTQLGAFYPFMRNHNDLNSVPQEPYRFSETAQQAMRKAFALRYALLPYLYTLFHRAHVRG
DTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTEVTGYFPKGTWYNMQMVSV
DSLGTLPSPSSASSFRSAVQSKGQWLTLEAPLDTINVHLREGYIIPLQGPSLTTTESRKQ
PMALAVALTASGEADGELFWDDGESLAVLERGAYTLVTFSAKNNTIVNKLVRVTKEGAEL
QLREVTVLGVATAPTQVLSNGIPVSNFTYSPDNKSLAIPVSLLMGELFQISWS
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| BDBM50312527 |
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| n/a |
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| Name | BDBM50312527 |
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| Synonyms: | CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin |
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| Type | Small organic molecule |
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| Emp. Form. | C22H39NO5 |
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| Mol. Mass. | 397.5488 |
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| SMILES | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 |r,TLB:21:22:20.25.19:26,THB:21:20:22.23.27:26,23:22:19:25.24.26,23:24:21.22.27:19| |
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| Structure | 
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