Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50335620

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_715435 (CHEMBL1664820)

19.9±n/a nM

Citation

Herold, F; Chodkowski, A; Izbicki, L; Turlo, J; Dawidowski, M; Kleps, J; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Mazurek, AP; Mazurek, A; Plucinski, F Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3. Eur J Med Chem46:142-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50335620

n/a

Name

BDBM50335620

Synonyms:

2-(4-(4-(1H-indol-3-yl)piperidin-1-yl)butyl)-4-(2-methoxyphenyl)-5,6,7,8-tetrahydro-1H-pyrido[1,2-c]pyrimidine-1,3(2H)-dione | CHEMBL1651735

Type

Small organic molecule

Emp. Form.

C32H38N4O3

Mol. Mass.

526.6691

SMILES

COc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCC(CC2)c2c[nH]c3ccccc23)c1=O |(.87,-34.6,;-.47,-35.37,;-1.8,-34.61,;-1.81,-33.06,;-3.14,-32.29,;-4.47,-33.06,;-4.47,-34.61,;-3.14,-35.38,;-3.15,-36.91,;-4.48,-37.68,;-5.81,-36.91,;-7.14,-37.67,;-7.14,-39.21,;-5.81,-39.98,;-4.49,-39.21,;-3.16,-39.99,;-3.16,-41.53,;-1.82,-39.22,;-.49,-40,;.85,-39.23,;2.18,-40.01,;3.52,-39.24,;4.85,-40.02,;4.84,-41.56,;6.16,-42.33,;7.5,-41.57,;7.51,-40.03,;6.18,-39.25,;8.83,-42.35,;8.98,-43.88,;10.49,-44.21,;11.26,-42.88,;12.76,-42.58,;13.25,-41.13,;12.23,-39.97,;10.73,-40.28,;10.25,-41.73,;-1.81,-37.68,;-.48,-36.91,)|

Structure