| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14-alpha demethylase |
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| Ligand | BDBM31772 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_721239 (CHEMBL1675116) |
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| Kd | 200±n/a nM |
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| Citation |  Warrilow, AG; Jackson, CJ; Parker, JE; Marczylo, TH; Kelly, DE; Lamb, DC; Kelly, SL Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. Antimicrob Agents Chemother53:1157-64 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol 14-alpha demethylase |
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| Name: | Lanosterol 14-alpha demethylase |
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| Synonyms: | CP51_MYCTO | CYPLI | Cytochrome P450 51(CYP51) | P450-14DM | P450-LIA1 | Sterol 14-alpha demethylase | cyp51 |
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| Type: | Monooxygenase; oxidoreductase |
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| Mol. Mass.: | 50869.67 |
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| Organism: | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
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| Description: | P9WPP8 |
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| Residue: | 451 |
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| Sequence: | MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE
FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA
YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR
FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA
LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP
DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA
QPPESYRNDHSKMVVQLAQPACVRYRRRTGV
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| BDBM31772 |
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| n/a |
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| Name | BDBM31772 |
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| Synonyms: | 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid | Brentan | CHEMBL91 | Dactarin | Miconazole | US9138393, Miconazole Nitrate | US9144538, Miconazole Nitrate | cid_4189 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl4N2O |
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| Mol. Mass. | 416.129 |
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| SMILES | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 |
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| Structure | 
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