| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM18070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_723694 (CHEMBL1677364) |
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| IC50 | 2.2±n/a nM |
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| Citation |  Bourne, CR; Barrow, EW; Bunce, RA; Bourne, PC; Berlin, KD; Barrow, WW Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother54:3825-33 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA |
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| Type: | Enzyme |
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| Mol. Mass.: | 18249.71 |
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| Organism: | Staphylococcus aureus |
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| Description: | n/a |
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| Residue: | 159 |
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| Sequence: | MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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| BDBM18070 |
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| n/a |
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| Name | BDBM18070 |
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| Synonyms: | 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine | AR-100 | Iclaprim |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N4O3 |
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| Mol. Mass. | 354.403 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)c2C=CC(Oc2c1OC)C1CC1 |c:16| |
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| Structure | 
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