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TargetLanosterol 14a-demethylase
LigandBDBM50333117
Substrate/Competitorn/a
Meas. Tech.ChEMBL_724288 (CHEMBL1677681)
Kd 423±n/a nM
Citation Warrilow, AG; Melo, N; Martel, CM; Parker, JE; Nes, WD; Kelly, SL; Kelly, DE Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother54:4225-34 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lanosterol 14a-demethylase
Name:Lanosterol 14a-demethylase
Synonyms:14-alpha sterol demethylase
Type:PROTEIN
Mol. Mass.:58939.22
Organism:Neosartorya fumigata
Description:ChEMBL_724288
Residue:524
Sequence:
MGLIAFILDGICKHCSTQSTWVLVGIGLLSILAVSVIINVLQQLLFKNPHEPPVVFHWFP
FIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEE
VYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAF
QGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLDMGFAPINFMLPWAP
LPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVYKNGTPVPDEEIAHM
MIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHA
KVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWN
PHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVL
VRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSFVEFEKRESATKA
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  Blast E-value cutoff:
BDBM50333117
n/a
NameBDBM50333117
Synonyms:(2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | (2R,3S)-2-(2,4-Difluoro-phenyl)-3-(5-fluoro-pyrimidin-4-yl)-1-[1,2,4]triazol-1-yl-butan-2-ol | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | CHEMBL638 | UK-109496 | US11247981, Example Voriconazole | US9221791, Voriconazole | VORICONAZOLE | Vfend
TypeSmall organic molecule
Emp. Form.C16H14F3N5O
Mol. Mass.349.3105
SMILESC[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F |r|
Structure
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