| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14a-demethylase |
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| Ligand | BDBM31774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_724295 (CHEMBL1677688) |
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| Kd | 103±n/a nM |
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| Citation |  Warrilow, AG; Melo, N; Martel, CM; Parker, JE; Nes, WD; Kelly, SL; Kelly, DE Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother54:4225-34 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol 14a-demethylase |
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| Name: | Lanosterol 14a-demethylase |
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| Synonyms: | 14-alpha sterol demethylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58939.22 |
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| Organism: | Neosartorya fumigata |
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| Description: | ChEMBL_724288 |
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| Residue: | 524 |
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| Sequence: | MGLIAFILDGICKHCSTQSTWVLVGIGLLSILAVSVIINVLQQLLFKNPHEPPVVFHWFP
FIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEE
VYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAF
QGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLDMGFAPINFMLPWAP
LPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVYKNGTPVPDEEIAHM
MIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHA
KVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWN
PHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVL
VRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSFVEFEKRESATKA
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| BDBM31774 |
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| n/a |
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| Name | BDBM31774 |
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| Synonyms: | CHEMBL104 | Canesten | Clotrimazole | Lotrimin | Mycelex | US9138393, Clotrimazole | cid_2812 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClN2 |
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| Mol. Mass. | 344.837 |
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| SMILES | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 |
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| Structure | 
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