Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50336696 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_723169 (CHEMBL1675391) |
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Ki | 4.4±n/a nM |
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Citation | Michel, K; Büther, K; Law, MP; Wagner, S; Schober, O; Hermann, S; Schäfers, M; Riemann, B; Höltke, C; Kopka, K Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. J Med Chem54:939-48 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10 |
Type: | PROTEIN |
Mol. Mass.: | 48591.87 |
Organism: | Mus musculus |
Description: | ChEMBL_723169 |
Residue: | 427 |
Sequence: | MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERS
SHKDSMN
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BDBM50336696 |
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n/a |
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Name | BDBM50336696 |
Synonyms: | 3-Benzo[1,3]dioxol-5-yl-4-[3-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)-ethyl]-1H-1,2,3-triazol-4-ylmethoxy}ethoxy)ethoxy]ethoxy}ethoxy)-4,5-dimethoxybenzyl]-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one | CHEMBL1672882 |
Type | Small organic molecule |
Emp. Form. | C51H61FN4O17 |
Mol. Mass. | 1021.045 |
SMILES | COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OCCOCCOCCOCCOCc2cn(CCOCCOCCOCCOc3cccnc3F)nn2)c1)c1ccc2OCOc2c1 |c:14| |
Structure |
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