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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Adenosine receptor A2b | ||
| Ligand | BDBM50336981 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_719009 (CHEMBL1679071) | ||
| Ki | 26±n/a nM | ||
| Citation |  Eastwood, P; Esteve, C; González, J; Fonquerna, S; Aiguadé, J; Carranco, Is; Doménech, T; Aparici, Ms; Miralpeix, M; Albertí, J; Córdoba, M; Fernández, R; Pont, Ms; Godessart, Ns; Prats, N; Loza, Ms; Cadavid, Ms; Nueda, A Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist ACS Med Chem Lett2:213-218 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Adenosine receptor A2b | |||
| Name: | Adenosine receptor A2b | ||
| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 36341.22 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 332 | ||
| Sequence: |
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| BDBM50336981 | |||
| n/a | |||
| Name | BDBM50336981 | ||
| Synonyms: | CHEMBL1672629 | N-[5-(3,5-Difluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropane carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H13F2N5O | ||
| Mol. Mass. | 353.3255 | ||
| SMILES | Fc1cncc(F)c1-c1ncc(NC(=O)C2CC2)nc1-c1cccnc1 |(-1.07,4.1,;-2.52,3.57,;-3.7,4.56,;-5.15,4.04,;-5.41,2.52,;-4.23,1.53,;-4.76,.08,;-2.79,2.06,;-1.25,.77,;.08,1.54,;1.41,.77,;1.41,-.77,;2.75,-1.54,;4.08,-.77,;5.41,-1.54,;4.08,.77,;4.85,2.1,;3.31,2.1,;.08,-1.54,;-1.25,-.77,;-2.79,-2.06,;-4.23,-1.53,;-5.41,-2.52,;-5.15,-4.04,;-3.7,-4.56,;-2.52,-3.57,)| | ||
| Structure | 
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